Metabolic syndrome is a cluster of risk factors which can result in heart disease and diabetes. Researchers have now found that poor diet and lack of exercise that lead to an imbalance in metabolism may also increase a child's risk of developing asthma.
Dr. Giovanni Piedimonte and researchers from West Virginia University School of Medicine analyzed data from nearly 18,000 children aged 4 to 12 years who were taking part in the Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) project. Factors considered included triglyceride levels and evidence of acanthosis nigricans, which are raised patches of brown skin that are often biomarkers for insulin resistance.
The team also considered body mass index or BMI, and almost 21% of the children were considered obese. Fourteen percent of the children had asthma.
The researchers found that asthma prevalence among the children was strongly associated with certain symptoms of metabolic syndrome including dyslipidemia and abnormal glucose metabolism, but not weight status. Although those who were obese were more likely to have asthma, even children of a healthy weight who had imbalanced metabolism were at increased risk.
Certain metabolic factors participate in the asthma disease process by contributing to inflammation of the airways in the lungs and hyperreactivity (contraction of smooth muscle in the bronchial walls), says Dr. Piedimonte. He says that strict monitoring and control of triglyceride and glucose levels early in life may play a role in the management of chronic asthma in children.
Dr. Piedimonte would like to see the findings used as further support for universal lipid screening in children. “The rationale is that by using selective screening, we would have missed over a third of children with significant genetic dyslipidemia,” he said.
Both poor diet – one lacking in antioxidants but high in fat – and inadequate exercise play a role in the metabolic syndrome, a group of risk factors that increase the risk for coronary artery disease, stroke, and type 2 diabetes. The goal of treatment is often weight loss (if overweight), a minimum of 30 minutes of daily moderate intensity exercise, and a lowering of cholesterol, blood pressure and blood sugar through diet or medication.
Cottrell L, et al “Metabolic abnormalities in children with asthma” Am J Respir Crit Care Med 2010; DOI: 10.1164/rccm.201004-0603OC.
The new study looked into the effects of four different diet combinations on blood lipid metabolism, in 117 patients with metabolic syndrome.
In accordance with previous suggestions, the researchers found that a low-fat, high-complex carbohydrate diet had “several detrimental effects”, including significantly increasing total triglyceride levels, and triglyceride rich lipoprotein cholesterol levels.
In contrast, intake of the same diet supplemented with omega-3 was found to have no effects on blood lipid levels, with researchers observing that a diet rich in monounsaturated fats, or a low-fat diet rich in complex carbohydrates and omega-3 fatty acids, resulted in lower circulating blood lipid levels than a diet rich in high saturated fats or a diet low in fats and high in complex carbohydrates.
The data from the study suggest a place for higher omega-3 intake in people with metabolic syndrome, and supports previous research that suggests monounsaturated fatty acids can have a positive effect on blood lipid levels.
“The long-term effect of the low-fat, high-complex carbohydrate diet, pre vs. post intervention phases, showed several beneficial effects of long chain omega-3 PUFA supplementation,” stated the researchers.
“Our data suggest that long-term intake of an isocaloric, low-fat, high-carbohydrate diet supplemented with long chain omega-3 … have beneficial effects on postprandial lipoprotein response in patients with metabolic syndrome,”
Source: The Journal of Nutrition
“A Low-Fat, High-Complex Carbohydrate Diet Supplemented with Long-Chain (n-3) Fatty Acids Alters the Postprandial Lipoprotein Profile in Patients with Metabolic Syndrome”
Authors: Y. Jimenez-Gomez, C. Marin, P. Perez-Martinez, et al