Drinking soft drinks is associated with higher blood pressure, according to a study of over 2,500 people reported this week in the journal Hypertension. High blood pressure is a major risk factor for heart disease, which is the leading cause of death worldwide. Someone with a blood pressure level in millimetres of mercury (mmHg) of 135 over 85 is twice as likely to have a heart attack or stroke as someone with a reading of 115 over 75.
The new research shows that for every extra can of soft drink consumed per day, participants on average had a higher systolic blood pressure by 1.6 mmHg and a higher diastolic blood pressure by 0.8 mmHg. This difference was statistically significant even after adjusting for factors such as weight and height. The study did not examine the mechanism that might link soft drinks with blood pressure. However, the researchers suggest that raised uric acid, which has been linked to soft drink consumption, might raise blood pressure by reducing the levels of nitric oxide, a chemical that relaxes the lining of the blood vessels.
The association between soft drinks and higher blood pressure was especially strong in people who consumed a lot of salt as well as sugar. Diet drinks were linked with lower blood pressure levels in some analyses, but the association was not consistent or strong. Professor Paul Elliott, senior author of the study, from the School of Public Health at Imperial College London, said: “It’s widely known that if you have too much salt in your diet, you’re more likely to develop high blood pressure. The results of this study suggest that people should be careful about how much sugar they consume as well.”
The researchers analysed data from 2,696 volunteers aged between 40 and 59, in eight areas of the US and two areas of the UK. On four separate occasions over a period of three weeks on average, the participants reported what they had eaten in the preceding 24 hours, as well as giving urine samples and having their blood pressure measured. The volunteers were taking part in INTERMAP, the International Study of Macronutrients, Micronutrients and Blood Pressure.
The researchers also found that people who drink more soft drinks tended to have more unhealthy diets in general. As well as consuming more sugar, those consuming more than one soft drink a day consumed more calories by 397 kilocalories per day on average, and less fibre and minerals. Those who did not consume soft drinks had a lower body mass index (BMI) on average than those who consumed more than one drink per day. “Individuals who drink a lot of sugar-sweetened beverages appear to have less healthy diets,” said Dr Ian Brown, the study’s first author, also from the School of Public Health at Imperial College London. “They are consuming empty calories without the nutritional benefits of real food. They consume less potassium, magnesium and calcium.” “This is a population study,” Dr Brown added. “It can’t say definitively that sugary drinks raise your blood pressure, but it’s one piece of the evidence in a jigsaw puzzle that needs to be completed. In the meantime, we would advise people who want to drink sugar-sweetened beverages should do so only in moderation.”
Researchers have a new theory on why some kids get unexplained tummy aches.
In some people, the small intestine is unable to efficiently break down fructose (and sometimes other forms of sugar). This problem is sometimes referred to as fructose intolerance. The undigested fructose passes into the large intestine, where it is broken down by bacteria. A by-product of this process is the creation of carbon dioxide and hydrogen. These two gases build up in the intestine, causing bloating, gas, pain and diarrhea. In some cases, the problem can affect absorption of important nutrients, like calcium and iron.
Researchers estimate about 33 percent of Americans have some level of sensitivity to sugar, most commonly to fructose, but the symptoms are often vague. Some people with fructose intolerance can eat small amounts of the sugar and not have any problems, making diagnosis even trickier.
Daniel Lustig, M.D., Pediatric Gastroenterologist at Mary Bridge Children’s Health Center in Tacoma, WA, says patients with chronic digestive problems should have a physician’s evaluation to rule out other possible causes of the symptoms, like Celiac disease or Crohn’s disease. Once those conditions have been ruled out, he recommends a diagnostic tool called the breath hydrogen test.
A patient is given a dose of fructose. Then, periodically, he/she breathes into an air collection bag. The gases from the bag are retrieved and analyzed for the presence of hydrogen (one of the gases given off when fructose is broken down in the large intestine). Patients whose hydrogen levels exceed 20 points beyond a baseline reading are likely to be fructose intolerant.
Lustig explains the main treatment of fructose intolerance is avoidance of foods containing fructose. That includes fruits, fruit juices, sodas and processed foods and drinks with high fructose corn syrup. Since fructose is in so many foods, it can be tricky to find and hard to avoid.
Lustig recently performed a study to look at possible fructose intolerance in 245 children and adolescents (ages 2 to 18) with unexplained chronic abdominal pain, gas or bloating. The breath hydrogen test found that nearly 54 percent of the participants tested positive for fructose intolerance. Lustig says the problem appeared to be especially high among teen girls.
Those who were judged to be fructose intolerant were given advice on using a low-fructose diet. The investigators found that nearly 68 percent of those who followed the recommended diet had an improvement or resolution in their symptoms.
Excessive intake of sugar-sweetened beverages like soft drinks and fruit juices that offer no nutritional value other than calories to the diet of teenagers can elevate their risk of heart disease in later life, claims a new study. According to health experts, there is growing evidence of the link between excess sugar consumption among youngsters and a number of health conditions such as obesity, hypertension, elevated triglycerides that are considered markers for heart disease. Lead author of the study, Jean Welsh, post-doctoral fellow at Emory University School of Medicine in Atlanta stated, “We need to be aware of sugar consumption. “It’s a significant contributor of calories to our diet and there are these associations that may prove to be very negative. “Sugar-sweetened soft drinks and sodas are the major contributor of added sugar and are a major source of calories without other important nutrients. “Parents and adolescents need to become aware of the amount of added sugar they are consuming and be aware that there may be some negative health implications if not now, then down the line.”
According to the American Heart Association (AHA) recommendations, a teenager who requires 2,200 calories may have an upper limit of 150 calories from added sugar while someone with an energy requirement of 1,800 calories per day should limit added sugar to 100 calories. However, the National Health and Nutrition Survey (NHANES) of 2,157 teenagers aged 12 to 18 years found that the average teenager consumes close to 500 calories added sugars each day. “Adolescents are eating 20 per cent of their daily calories in sugars that provide few if any other nutrients,” said Jean Welsh.
In order to get an insight into the impact of high sugar consumption in adolescence on the risk of cardiovascular disease in later life the researchers studied 646 teenagers. For the purpose of the study, they analyzed the 24-hour dietary recall by teens with data from the US Department of Agriculture on sugar content in foods. It was noted that the teens’ average daily consumption of added sugars was three to five times higher that the limit acceptable by the AHA.
The study found, that teens who consumed 30 percent or more of total calories from added sugars exhibited lower levels of HDL, or “good” cholesterol and higher levels of triglycerides and LDL or “bad” cholesterol, compared to those who ate less than 10 percent of added sugar. In addition, it was observed that obese and overweight teenagers who consumed more sugar also had the most insulin resistance.
Although the study hints at a possible association between added sugar intake and poor cholesterol profiles as well as other heart disease risk factors, researchers feel there is need for more research to substantiate the findings. Welsh stated, “We need controlled studies to really understand the role of added sugars in cardiovascular disease. But it is important to be aware of the added sugar in the foods we all eat.”
The study is published in the American Heart Association (AHA) journal ‘Circulation.’
Teens whose diets include lots of sugary drinks and foods show physical signs that they are at increased risk for heart disease as adults, researchers from Emory University report. Among 2,157 teens who took part in the National Health and Nutrition Examination Survey, the average amount of added sugar eaten in a day was 119 grams (476 calories), which was 21.4 percent of all the calories these teens consumed daily, the researchers noted. “We need to be aware of sugar consumption,” said lead researcher and postdoctoral fellow Jean Welsh. “It's a significant contributor of calories to our diet and there are these associations that may prove to be very negative,” she said. “Sugar-sweetened soft drinks and sodas are the major contributor of added sugar and are a major source of calories without other important nutrients.” Awareness of the negative effects of added sugar may help people, particularly teens, cut down on the amount of sugar they consume, Welsh added. “Parents and adolescents need to become aware of the amount of added sugar they are consuming and be aware that there may be some negative health implications if not now, then down the line,” she said.
The report is published in the Jan. 10 online edition of Circulation.
Welsh's team found that teens who consumed the most added sugar had 9 percent higher LDL (“bad”) cholesterol levels, and 10 percent higher triglyceride levels (another type of blood fat), compared with those who consumed the least added sugar. Teens who took in the highest amount of added sugar also had lower levels of HDL (“good”) cholesterol than those who consumed the least amount of added sugar. In addition, teens who consumed the highest amount of added sugar showed signs of insulin resistance, which can lead to diabetes and its associated risk of heart disease, the researchers found.
The American Heart Association has recommended an upper limit for added sugars intake, based on the number of calories you need. “Most American women [teens included] should consume no more than 100 calories of added sugars per day; most men, no more than 150 calories,” the association states.
One caveat to these findings is that because of the way the study was done it is not clear if added sugars caused the differing cholesterol levels, only that they are linked. In addition, the data are only for one day and may not reflect the teen's usual diet, the researchers noted. Commenting on the study, Dr. David L. Katz, director of the Prevention Research Center at Yale University School of Medicine, said that “this study does not prove that dietary sugar is a cardiac risk factor in this population, but it strongly suggests it.”
The paper has three important messages, he said. First, dietary sugar intake in a representative population of teenagers is nearly double the recommended level. Second, the higher the intake of sugar, the greater the signs of cardiac risk, including elevated LDL (“bad”) cholesterol and low HDL (“good”) cholesterol. Third, the apparent harms of excess sugar are greater in overweight than in lean adolescents.
“Sugar is by no means the sole dietary threat to the health of adolescents, or adults,” Katz said. “But we now have evidence it certainly counts among the important threats to both. Reducing sugar intake by adolescents, to prevent them becoming adults with diabetes or heart disease, is a legitimate priority in public health nutrition,” he said.
SOURCES: HealthDay; Jean Welsh, M.P.H., Ph.D., R.N., postdoctoral fellow, Emory University, Atlanta; David L. Katz, M.D., M.P.H., director, Prevention Research Center, Yale University School of Medicine, New Haven, Conn.; Jan. 10, 2011, Circulation, online
A new study has claimed that an ingredient of dark chocolate could assist in the control of severely high cholesterol levels, a major problem for those suffering from diabetes. Previous research has highlighted that chocolate which contains a high level of cocoa solids rich in polyphenols may be able to reduce the risk of heart disease, and this study, published in the journal Diabetic Medicine, saw a reduction in cholesterol for a small number of diabetics given chocolate that contained a lot of the chemical.
The researchers, from Hull University, examined 12 patients with type 2 diabetes who were given identical chocolate bars, some of which were enriched with polyphenols. The patients that consumed the enriched bars experienced a small improvement in their overall cholesterol rating, with a drop in total cholesterol while the level of good cholesterol increased.
Steve Atkin, who led the study, said “Chocolate with a high cocoa content should be included in the diet of individuals with type 2 diabetes as part of a sensible, balanced approach to diet and lifestyle.” However, the charity Diabetes UK warned that these findings may mislead people into eating too much chocolate, arguing that the high fat and sugar content probably outweighed any benefits.
Dr Iain Frame, director of research at Diabetes UK, commented “On no account should people take away the message from this study, conducted in only 12 people, that eating even a small amount of dark chocolate is going to help reduce their cholesterol levels.” He added “It would, however, be interesting to see if further research could find a way of testing whether polyphenols could be added to foods which weren’t high in sugar and saturated fat such as chocolate”.
Bouhlal and co workers reported that salt had an impact on intake but fat did not. They found that in general food intake increased with salt level, noting that compared with the 'normal' salt levels, a suppression of salt induced a 25 per cent decrease in green bean intake, whereas an addition of salt induced a 15 per cent increase in pasta intake. Contrarily to initial beliefs, the researchers observed no increase in food intake with increasing added sugar level. They said the findings indicate that two to three year old children's food intake may not be affected by its added sugar content.
The study data also showed that preschool children with a higher BMI score consumed more pasta when fat level was higher. The authors said this finding may confirm previous results which highlight fatter children prefer high-fat foods. The researcher said their results imply that fat and sugar addition could be avoided in foods for children without having an impact on palatability, allowing the energy density of children's diet to be limited.
“Furthermore, these findings suggest that there is no need to add salt to pasta which is consumed anyway. On the contrary, salt suppression in vegetables, whose intake is to be promoted, should be considered cautiously,” they said.
Source: British Journal of Nutrition
Published online ahead of print, doi: 10.1017/S0007114510003752
“The impact of salt, fat and sugar levels on toddler food intake”
Authors: S. Bouhlal, S. Issanchou, S. Nicklaus
Eating a Mediterranean-style diet may help people with type 2 diabetes keep their disease under control without drugs better than following a typical low-fat diet.A new study from Italy shows that people with type 2 diabetes who ate a Mediterranean diet rich in vegetables and whole grains with at least 30% of daily calories from fat (mostly olive oil) were better able to manage their disease without diabetes medications than those who ate a low-fat diet with no more than 30% of calories from fat (with less than 10% coming from saturated fat choices).
After four years, researchers found that 44% of people on the Mediterranean diet ended up requiring diabetes medications to control their blood sugars compared with 70% of those who followed the low-fat diet.
It’s one of the longest-term studies of its kind, and researchers, including Katherine Esposito, MD, of the Second University of Naples, say the results “reinforce the message that benefits of lifestyle interventions should not be overlooked.”
Best Diet for Diabetes Control
In the study, researchers randomly assigned 215 overweight people recently diagnosed with type 2 diabetes who had never been treated with diabetes medications to either a Mediterranean-style diet or a low-fat diet.
The Mediterranean diet was rich in vegetables and whole grains and low in red meat, which was replaced with fish or poultry. Overall, the diet consisted of no more than 50% of daily calories from carbohydrates and no less than 30% of calories from fat.
The low-fat diet was based on American Heart Association guidelines and was rich in whole grains and limited in sweets with no more than 30% of calories from fat and 10% from saturated fats, such as animal fats.
After four years of follow-up, the Mediterranean diet group had better glycemic (blood sugar) control and were less likely to require diabetes medications to bring their blood sugar within healthy levels.
In addition, people who followed the Mediterranean diet group also experienced improvement in other heart disease risk factors. Interestingly, weight loss was relatively comparable between the two groups by the end of the trial, suggesting that attributes of the Mediterranean diet beyond weight loss affect blood sugar control.
SOURCES: Esposito, K. Annals of Internal Medicine, Sept. 1, 2009; vol 151: pp 306-315. News release, American College of Physicians.
Nutrition experts at Oregon State University have essentially “cured” laboratory mice of mild, diet-induced diabetes by stimulating the production of a particular enzyme. The findings could offer a new approach to diabetes therapy, experts say, especially if a drug could be identified that would do the same thing, which in this case was accomplished with genetic manipulation.
Increased levels of this enzyme, called fatty acid elongase-5, restored normal function to diseased livers in mice, restored normal levels of blood glucose and insulin, and effectively corrected the risk factors incurred with diet-induced diabetes. “This effect was fairly remarkable and not anticipated,” said Donald Jump, a professor of nutrition and exercise sciences at Oregon State, where he is an expert on lipid metabolism and principal investigator with OSU’s Linus Pauling Institute. “It doesn’t provide a therapy yet, but could be fairly important if we can find a drug to raise levels of this enzyme,” Jump said. “There are already some drugs on the market that do this to a point, and further research in the field would be merited.”
The studies were done on a family of enzymes called “fatty acid elongases,” which have been known of for decades. Humans get essential fatty acids that they cannot naturally make from certain foods in their diet. These essential fatty acids are converted to longer and more unsaturated fatty acids. The fatty acid end products of these reactions are important for managing metabolism, inflammation, cognitive function, cardiovascular health, reproduction, vision and other metabolic roles.
The enzymes that do this are called fatty acid elongases, and much has been learned in recent years about them. In research on diet-induced obesity and diabetes, OSU studied enzyme conversion pathways, and found that elongase-5 was often impaired in mice with elevated insulin levels and diet-induced obesity.
The scientists used an established system, based on a recombinant adenovirus, to import the gene responsible for production of elongase-5 into the livers of obese, diabetic mice. When this “delivery system” began to function and the mice produced higher levels of the enzyme, their diet-induced liver defects and elevated blood sugar disappeared.
“The use of a genetic delivery system such as this was functional, but it may not be a permanent solution,” Jump said. “For human therapy, it would be better to find a drug that could accomplish the same thing, and that may be possible. There are already drugs on the market, such as some fibrate drugs, that induce higher levels of elongase-5 to some extent.”
There are also drugs used with diabetic patients that can lower blood sugar levels, Jump said, but some have side effects and undesired complications. The potential for raising levels of elongase-5 would be a new, specific and targeted approach to diabetes therapy, he said. While lowering blood sugar, the elevated levels of elongase-5 also reduced triglycerides in the liver, another desirable goal. Elevated triglycerides are associated with “fatty liver,” also known as non-alcoholic fatty liver disease. This can progress to more severe liver diseases such as fibrosis, cirrhosis and cancer.
Further research is needed to define the exact biological mechanisms at work in this process, and determine what the fatty acids do that affects carbohydrate and triglyceride metabolism, he said. It appears that high fat diets suppress elongase-5 activity.
“These studies establish a link between fatty acid elongation and hepatic glucose and triglyceride metabolism,” the researchers wrote in their report, “and suggest a role for regulators of elongase-5 activity in the treatment of diet-induced hyperglycemia and fatty liver.”
The study was published in the Journal of Lipid Research. The research was supported by the National Institutes of Health and the National Institute for Food and Agriculture of the U.S. Department of Agriculture.
Steering clear of full-fat, fried, and processed foods is not just good for overall health, it could help prevent chronic lung conditions, a large UK study has revealed.
Led by Seif Shaheen, Professor of Respiratory Epidemiology at Barts and The London School of Medicine, the study – involving 1,551 men and 1,391 women with an average age of 66 – showed that those whose diet favoured fresh fruit and vegetables, oily fish and wholegrain products had far better lung function than those who chose a diet high in fat, sugar and processed food.
The diets of those involved were investigated to assess what kinds of food they consumed on a regular basis. Their lung function was also tested using a spirometer, a device which measures the amount of air that a person can blow out of their lungs in one second. This simple test illustrates how healthy the lungs are, and determines whether any blockage or obstruction exists in the airways. If the airways are obstructed, the person is diagnosed with Chronic Obstructive Pulmonary Disease (COPD).
The study also revealed that the beneficial effects of the sensible diet were particularly strong in men who smoked.
Lung health in particular may be positively affected by a sensible diet because of the antioxidants contained in fruit and wholegrains, and the omega-3 fatty acids found in oily fish – that protect the lungs against the adverse effects of smoking.
Professor Shaheen said: “Whilst cessation of smoking is still the number one way to improve lung health, this study is important because it suggests that cases of COPD might be prevented if people, especially male smokers, ate more fruit and vegetables, oily fish and wholegrain cereals, and less white bread, sugar, full fat dairy products, fried food and processed meat. However, the only way to confirm this would be to carry out a randomised controlled trial.”