All Posts tagged expectant

Pesticides linked to ADHD

Organophosphate pesticides act by disrupting neurotransmitters, particularly acetylcholine, which plays an important role in sustaining attention and short-term memory.

“Given that these compounds are designed to attack the nervous system of organisms, there is reason to be cautious, especially in situations where exposure may coincide with critical periods of fetal and child development,” said he study's lead author Amy Marks.

Earlier this year, a different study by researchers at Harvard University associated greater exposure to organophosphate pesticides in school aged children with higher rates of attention deficit hyperactivity disorder (ADHD) symptoms.

“These studies provide a growing body of evidence that organophosphate pesticide exposure can impact human neurodevelopment, particularly among children. We were especially interested in prenatal exposure because that is the period when a baby's nervous system is developing the most,” said Eskenazi.

More than 300 children were tested and the researchers were continuing to follow the children as they get older and expect to present more results in the years to come. The current findings were published in the journal Environmental Health Perspectives.

Source: New York Post

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Gestational Diabetes Can Be Prevent by Dietary Changes

According to UCSF Professor Michael German, MD, who is also the senior author of the paper, tryptophan hydroxylase (Tph1), the enzyme that produces serotonin from tryptophan increased by as much 1000-fold during the early pregnancy. The researchers found that inhibition of serotonin synthesis by restricting the intake of tryptophan in pregnant mice blocked beta cell proliferation and resulted in the development of glucose intolerance and gestational diabetes in the mice.

The research indicates that anything that affects the production of serotonin, such as drugs, diet or genetic inheritance may affect the risk of developing gestational diabetes and possibly the long-term risk of developing type 2 diabetes.

Serotonin has been widely studied as a neurotransmitter in the brain for its effects on appetite and mood, especially depression. Since it also influences the insulin production, this could explain why some patients with gestational diabetes experience depression. This would also explain the effect of some classes of psychiatric medications on diabetes.

The study will be published in the upcoming issue of “Nature Medicine” and was published online on June 27, 2010.

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